Well, you're probably missing the right
MySQL Connector ODBC.
PIM Xtreme uses (and installs with every installer) the
MySQL ODBC Connector in order to access to the databse.
Older versions of PIM Xtreme used the
MySQL Connector ODBC 3.51, but since PIM Xtreme 0.8 the
MySQL Connector ODBC 5.1 is used. However, this new version should be installed along with PIM Xtreme.
Try checking at Programs and Features in Control Panel, and see if you have that connector (and that version 5.1) installed under the name "MySQL Connector/ODBC 5.1"
If not you can try re-installing PIM Xtreme 0.8 (no need to uninstall).
Or, you can download the connector separately and install it. It's REALLY simple.
You download it here:
MySQL Connector/ODBC 5.1 and follow the installation wizard
I know some people had trouble with the Connector on Vista, I'm not sure why yet.
Hope it helps. Please keep me posted!